Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 3/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRB | P28702 | 3/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 2/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207778 | 1.00 | RARG (0.34) | RARGRXRARXRBRXRGHDAC4 | |
| SCHEMBL30374496 | 0.83 | KMT2A (0.37) | HDAC4ALDH1A1CYP2C19TTR | |
| SCHEMBL19224610 | 0.83 | KMT2A (0.37) | HDAC4ALDH1A1CYP2C19TTR | |
| SCHEMBL19207714 | 0.80 | ATM (0.35) | ATMTDP1 | |
| SCHEMBL30929499 | 0.71 | HDAC4 (0.44) | RARGRXRARXRBRXRGHDAC4 | |
| SCHEMBL19207517 | 0.71 | ATM (0.34) | HDAC4ATMTDP1TTR | |
| SCHEMBL19207660 | 0.69 | HDAC4 (0.39) | HDAC4ALDH1A1ATMTDP1TTR | |
| SCHEMBL28706606 | 0.69 | HPD (0.30) | — | |
| SCHEMBL104470 | 0.67 | TDP1 (0.52) | ALDH1A1ATMTDP1TTR | |
| SCHEMBL31423850 | 0.66 | PKM (0.45) | ALDH1A1CYP2C19ATMTDP1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |