Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methapyrilene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 4/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
| ▸ | DRD1 | P21728 | 4/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 4/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methapyrilene SCHEMBL498484 | 0.99 | KDM4E (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL745149 | 0.99 | CYP2D6 (0.97) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL1074644 | 0.97 | CYP2D6 (0.95) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL7121305 | 0.93 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL28140755 | 0.93 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL4902232 | 0.89 | CYP2D6 (0.80) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL7297232 | 0.84 | CYP2D6 (0.73) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10674626 | 0.82 | CYP2D6 (0.70) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL7311717 | 0.81 | CYP2D6 (0.68) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Histapyrrodine SCHEMBL28086254 | 0.80 | HRH1 (0.64) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6219 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-20250381195-A1 | Methods of Treating Diabetic Macular Edema | UNM RAINFOREST INNOVATIONS (US) | 2025-12-18 | — | — | US | claimed |
| US-20250248938-A1 | MEDICAMENT DELIVERY FORMULATIONS, DEVICES AND METHODS | HONEYWELL INTERNATIONAL INC. (US) | 2025-08-07 | — | — | US | claimed |
| CN-119294686-B | Digital twinning-based shore power equipment management and control method and system | 广州南沙海港集装箱码头有限公司 | 2025-03-25 | — | — | CN | claimed |
| US-20250051430-A1 | NEUTRALIZATION OF ACYL-COA BINDING PROTEIN CONFERS AUTOPHAGY-DEPENDENT ORGAN PROTECTION | Institut National de la Santé et de la Recherche Médicale (FR) | 2025-02-13 | — | — | US | claimed |
| US-20250041208-A1 | NEW INJECTABLE COMBINATION FORMULATION | NANEXA AB (SE) | 2025-02-06 | — | — | US | claimed |
| CN-119294686-A | Digital twinning-based shore power equipment management and control method and system | 广州南沙海港集装箱码头有限公司 | 2025-01-10 | — | — | CN | claimed |
| EP-4475883-A1 | NEUTRALIZATION OF ACYL-COA BINDING PROTEIN CONFERS AUTOPHAGY-DEPENDENT ORGAN PROTECTION | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2024-12-18 | — | — | EP | claimed |
| WO-2024229174-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2024-11-07 | — | — | WO | claimed |
| WO-1996020405-A1 | A PROCESS AND TEST KIT FOR COCAINE DETECTION | IDENTA LTD. (IL) | 1996-07-04 | — | — | WO | claimed |
| US-5183665-A | Using antihistamine | NITTO DENKO CORPORATION (JP) | 1993-02-02 | — | — | US | claimed |
| EP-0201537-B1 | NOVEL USE OF ANTI-NAUSEA AND ANTI-EMETIC PHARMAZEUTICAL AGENTS. | NASTECH PHARMACEUTICAL COMPANY, INC. (US) | 1992-04-29 | — | — | EP | claimed |
| US-4749700-A | NASAL ADMINISTRATION LOWER DOSAGE | NASTECH PHARMACEUTICAL CO, INC. (US) | 1988-06-07 | — | — | US | claimed |
| EP-0201537-A4 | NOVEL USE OF ANTI-NAUSEA AND ANTI-EMETIC PHARMAZEUTICAL AGENTS. | NASTECH PHARM CO (US) | 1987-07-06 | — | — | EP | claimed |
| EP-0201537-A1 | NOVEL USE OF ANTI-NAUSEA AND ANTI-EMETIC PHARMAZEUTICAL AGENTS. | NASTECH PHARM CO (US) | 1986-11-20 | — | — | EP | claimed |
| WO-1986002553-A1 | NOVEL METHOD OF ADMINISTERING ANTI-NAUSEA AND ANTI-EMETIC PHARMACEUTICAL AGENTS AND NOVEL DOSAGE FORMS CONTAINING SAME | NASTECH PHARMACEUTICAL COMPANY, INC. (US) | 1986-05-09 | — | — | WO | claimed |
| US-4550067-A | Secondary battery | HITACHI, LTD. (JP) | 1985-10-29 | — | — | US | claimed |
| US-4104382-A | (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | claimed |
| US-4000302-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-12-28 | — | — | US | claimed |