Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methapyrilene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.95 |
| ▸ | DRD1 | P21728 | 4/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.95 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.95 |
| ▸ | HTR2A | P28223 | 3/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.95 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.95 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.95 |
| ▸ | HTR2C | P28335 | 2/20 | 0.95 |
| ▸ | HTR2B | P41595 | 2/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.95 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.95 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.95 |
| ▸ | HTR6 | P50406 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methapyrilene SCHEMBL19209 | 0.97 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL498484 | 0.96 | KDM4E (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL745149 | 0.96 | CYP2D6 (0.97) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL7121305 | 0.90 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL28140755 | 0.90 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL4902232 | 0.87 | CYP2D6 (0.80) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL7297232 | 0.82 | CYP2D6 (0.73) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL10674626 | 0.80 | CYP2D6 (0.70) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| SCHEMBL7311717 | 0.79 | CYP2D6 (0.68) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Histapyrrodine SCHEMBL28086254 | 0.78 | HRH1 (0.64) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9424999-B2 | Dye for photoelectric conversion device and photoelectric conversion device | ADEKA CORPORATION (JP) | 2016-08-23 | — | — | US | disclosed |
| EP-2372829-B1 | PIGMENT FOR USE WITH PHOTOELECTRIC CONVERSION ELEMENT, AND PHOTOELECTRIC CONVERSION ELEMENT | ADEKA CORP (JP) | 2015-08-19 | — | — | EP | disclosed |
| US-20150027542-A1 | DYE FOR PHOTOELECTRIC CONVERSION DEVICE AND PHOTOELECTRIC CONVERSION DEVICE | ADEKA CORPORATION (JP) | 2015-01-29 | — | — | US | disclosed |
| US-8912344-B2 | Dye for photoelectric conversion device and photoelectric conversion device | ADEKA CORPORATION (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8884029-B2 | Dye for photoelectric conversion device and photoelectric conversion device | ADEKA CORPORATION (JP) | 2014-11-11 | — | — | US | disclosed |
| EP-2330680-B1 | DYE FOR PHOTOELECTRIC CONVERSION ELEMENT AND PHOTOELECTRIC CONVERSION ELEMENT | TDK CORP (JP) | 2013-10-23 | — | — | EP | disclosed |
| WO-2013030553-A1 | DYE- SENSITIZED SOALR CELL | ISIS INNOVATION LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012156723-A1 | OPTOELECTRONIC DEVICE | ISIS INNOVATION LIMITED (GB) | 2012-11-22 | — | — | WO | disclosed |
| US-20110253218-A1 | DYE FOR PHOTOELECTRIC CONVERSION DEVICE AND PHOTOELECTRIC CONVERSION DEVICE | ADEKA CORPORATION (JP) | 2011-10-20 | — | — | US | disclosed |
| EP-2372829-A1 | PIGMENT FOR USE WITH PHOTOELECTRIC CONVERSION ELEMENT, AND PHOTOELECTRIC CONVERSION ELEMENT | TDK Corporation (JP) | 2011-10-05 | — | — | EP | disclosed |
| US-20110155249-A1 | DYE FOR PHOTOELECTRIC CONVERSION DEVICE AND PHOTOELECTRIC CONVERSION DEVICE | TDK CORPORATION (JP) | 2011-06-30 | — | — | US | disclosed |
| EP-2330680-A1 | DYE FOR PHOTOELECTRIC CONVERSION ELEMENT AND PHOTOELECTRIC CONVERSION ELEMENT | TDK Corporation (JP) | 2011-06-08 | — | — | EP | disclosed |
| US-20110056556-A1 | DYE-SENSITIZED SOLAR CELL AND METHOD FOR MANUFACTURING THE SAME | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) | 2011-03-10 | — | — | US | disclosed |
| EP-2276104-A1 | DYE-SENSITIZED SOLAR CELL AND METHOD FOR MANUFACTURING THE SAME | Konica Minolta Business Technologies, Inc. (JP) | 2011-01-19 | — | — | EP | disclosed |
| US-20100300529-A1 | DYE-SENSITIZED SOLAR CELL | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-12-02 | — | — | US | disclosed |
| US-6433357-B1 | Display device | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2002-08-13 | — | — | US | disclosed |
| EP-1129484-A1 | DISPLAY DEVICE | Koninklijke Philips Electronics N.V. (NL) | 2001-09-05 | — | — | EP | disclosed |
| WO-2001015233-A1 | DISPLAY DEVICE | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110155249-A1 | DYE FOR PHOTOELECTRIC CONVERSION DEVICE AND PHOTOELECTRIC CONVERSION DEVICE | INMT, HCN2, HCN1 | HRH1 3976/4885CYP2D6 1547/4885CHRM2 160/4885 |
| US-20110253218-A1 | DYE FOR PHOTOELECTRIC CONVERSION DEVICE AND PHOTOELECTRIC CONVERSION DEVICE | HCN1, HCN2, HCN3 | HRH1 3475/4885CYP2D6 1504/4885CHRM2 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.