Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methapyrilene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.80 |
| ▸ | DRD1 | P21728 | 4/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.80 |
| ▸ | HTR2A | P28223 | 3/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.80 |
| ▸ | HTR2C | P28335 | 2/20 | 0.80 |
| ▸ | HTR2B | P41595 | 2/20 | 0.80 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.80 |
| ▸ | HTR6 | P50406 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methapyrilene SCHEMBL19209 | 0.89 | CYP2D6 (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL498484 | 0.88 | KDM4E (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL745149 | 0.88 | CYP2D6 (0.97) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL1074644 | 0.87 | CYP2D6 (0.95) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL28140755 | 0.83 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL7121305 | 0.83 | CYP2D6 (0.86) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Methapyrilene SCHEMBL17979729 | 0.81 | CYP2D6 (0.52) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Fumaric Acid SCHEMBL29895368 | 0.80 | SMN1; SMN2 (0.62) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Pyrilamine SCHEMBL97902 | 0.77 | SMN1; SMN2 (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 | |
| Pyrilamine SCHEMBL27430 | 0.77 | SMN1; SMN2 (1.00) | CYP2D6CHRM2ADRA2ADRD1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9492541-B2 | Phenylepherine containing dosage form | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2016-11-15 | — | — | US | claimed |
| US-20060057205-A1 | Phenylepherine containing dosage form | SOVEREIGN PHARMACEUTICALS, LTD. (US) | 2006-03-16 | — | — | US | claimed |
| WO-2006022996-A2 | DOSAGE FORM CONTAINING MULTIPLE DRUGS | SOVEREIGN PHARMACEUTICALS, LTD. (US) | 2006-03-02 | — | — | WO | claimed |
| EP-0081823-A1 | Composition for reducing menstrual pain | WHITBY RESEARCH, Inc. (US) | 1983-06-22 | — | — | EP | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |
| US-10098856-B2 | Alternating sympathomimetic therapy for the treatment of respiratory ailments | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2018-10-16 | — | — | US | disclosed |
| US-9492541-B2 | Phenylepherine containing dosage form | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160271078-A1 | ALTERNATING SYMPATHOMIMETIC THERAPY FOR THE TREATMENT OF RESPIRATORY AILMENTS | SOVEREIGN PHARMACEUTICALS, LLC | 2016-09-22 | — | — | US | disclosed |
| US-9364451-B1 | Alternating sympathomimetic therapy for the treatment of respiratory ailments | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2016-06-14 | — | — | US | disclosed |
| US-20150152348-A1 | SYSTEMS AND METHODS FOR COLLECTING, TRANSPORTING AND REPURPOSING OR DESTROYING UNUSED PHARMACEUTICALS | SHARPS COMPLIANCE, INC. OF TEXAS | 2015-06-04 | — | — | US | disclosed |
| US-8653135-B1 | Alternating sympathomimetic therapy for the treatment of respiratory aliments | SOVEREIGN PHARMACEUTICALS, LLC (US) | 2014-02-18 | — | — | US | disclosed |
| US-20080292699-A1 | SOLID PHARMACEUTICAL DOSAGE UNIT FOR ALLEVIATING SYMPTOMS OF RHINORRHEA | SOVEREIGN PHARMACEUTICALS, LTD. (US) | 2008-11-27 | — | — | US | disclosed |
| EP-0421582-A1 | Chewable spray dried spheroidal microcapsules and polymer coated microcapsules and method for preparing same | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| EP-0421581-A1 | Chewable spray dried spheroidal microcapsules and wax coated microcapsules and methods for preparing same | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |
| EP-0403048-A2 | Medicated compositions containing sucralfate and processes for their production | WARNER-LAMBERT COMPANY (US) | 1990-12-19 | — | — | EP | disclosed |
| US-4505862-A | ANALGESICS, SLEEPING MEDICATIONS | BRISTOL-MYERS COMPANY (US) | 1985-03-19 | — | — | US | disclosed |
| US-4401665-A | USING ASPIRIN AND/OR ACETAMINOPHEN MULTILAYER | BRISTOL-MYERS COMPANY (US) | 1983-08-30 | — | — | US | disclosed |
| EP-0081823-A1 | Composition for reducing menstrual pain | WHITBY RESEARCH, Inc. (US) | 1983-06-22 | — | — | EP | disclosed |
| US-4364945-A | ANTIHISTAMINE AND ISOMER OF VITAMIN E | WHITTLE BARRY J | 1982-12-21 | — | — | US | disclosed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | disclosed |