Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methapyrilene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.97 |
| ▸ | DRD1 | P21728 | 4/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.97 |
| ▸ | HTR2A | P28223 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | HTR2C | P28335 | 2/20 | 0.97 |
| ▸ | HTR2B | P41595 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methapyrilene SCHEMBL19209 | 0.99 | CYP2D6 (1.00) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| Methapyrilene SCHEMBL745149 | 0.97 | CYP2D6 (0.97) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| Methapyrilene SCHEMBL1074644 | 0.96 | CYP2D6 (0.95) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| Methapyrilene SCHEMBL7121305 | 0.91 | CYP2D6 (0.86) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| Methapyrilene SCHEMBL28140755 | 0.91 | CYP2D6 (0.86) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| Methapyrilene SCHEMBL4902232 | 0.88 | CYP2D6 (0.80) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| SCHEMBL7297232 | 0.83 | CYP2D6 (0.73) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| SCHEMBL10674626 | 0.81 | CYP2D6 (0.70) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| SCHEMBL7311717 | 0.80 | CYP2D6 (0.68) | KDM4EKMT2AMEN1NPSR1CYP2D6 | |
| Histapyrrodine SCHEMBL28086254 | 0.79 | HRH1 (0.64) | KDM4EKMT2AMEN1NPSR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3593 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4742350-A1 | ELECTROLYTE FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY INCLUDING THE SAME | SK On Co., Ltd. (KR) | 2026-05-13 | — | — | EP | claimed |
| US-20260112700-A1 | Electrolyte for Lithium Secondary Battery and Lithium Secondary Battery Including the Same | SK ON CO LTD (KR) | 2026-04-23 | — | — | US | claimed |
| CN-113113521-B | Light emitting device | 三星显示有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-119294686-B | Digital twinning-based shore power equipment management and control method and system | 广州南沙海港集装箱码头有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-119462729-A | Ladder alkenyl crosslinking comonomer, degradable PDCPD thermosetting material, preparation method and application | 安徽建筑大学 | 2025-02-18 | — | — | CN | claimed |
| CN-119294686-A | Digital twinning-based shore power equipment management and control method and system | 广州南沙海港集装箱码头有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-117887009-A | Preparation method and application of structure-controllable pigment hyper-dispersant | 浙江纳美新材料股份有限公司 | 2024-04-16 | — | — | CN | claimed |
| CN-117792809-A | Vehicle network management method, device, computer equipment and storage medium | 中国第一汽车股份有限公司 | 2024-03-29 | — | — | CN | claimed |
| CN-117586781-A | Liquid crystal composition, liquid crystal display element and application thereof | 捷恩智株式会社 | 2024-02-23 | — | — | CN | claimed |
| CN-116970406-A | Liquid crystal composition and liquid crystal element | 捷恩智株式会社 | 2023-10-31 | — | — | CN | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| WO-1998058685-A1 | DERMAL ADHESIVE PLASTER SUITABLE FOR TREATING LOCALIZED CUTANEOUS AFFECTIONS | LABORATORIO ITALIANO BIOCHIMICO FARMACEUTICO LISAPHARMA S.P.A. (IT) | 1998-12-30 | — | — | WO | claimed |
| CN-1182798-A | Method for producing natural abscisic acid by fungus fermentation | CHENGDU INST BIOLOGY CAS (CN) | 1998-05-27 | — | — | CN | claimed |
| CN-1118806-A | Method for extracting oil from tea-oil seed by using additive | ZHANG ZHIXIANG (CN) | 1996-03-20 | — | — | CN | claimed |
| CN-1095107-A | Seaweed beta-carotene production-agent increasing | INST OCEANOLOGY CHINESE ACAD (CN) | 1994-11-16 | — | — | CN | claimed |
| US-4654209-A | NITROGLYCERINE PLUS STEROID, ANTIHISTAMINE, ANALGESIC, ANTIMICROBIAL | EUROCELTIQUE, S.A. (LU) | 1987-03-31 | — | — | US | claimed |
| US-4550067-A | Secondary battery | HITACHI, LTD. (JP) | 1985-10-29 | — | — | US | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |