Methapyrilene

Methapyrilene

SCHEMBL745149

CN(C)CCN(Cc1cccs1)c1ccccn1.CN(C)CCN(Cc1cccs1)c1ccccn1.S

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Methapyrilene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 3/20 0.97
CYP2D6 P10635 6/20 0.97
CHRM2 P08172 4/20 0.97
ADRA2A P08913 4/20 0.97
DRD1 P21728 4/20 0.97
SLC6A4 P31645 4/20 0.97
SLC6A3 Q01959 4/20 0.97
KCNH2 Q12809 4/20 0.97
SLC6A2 P23975 3/20 0.97
HTR2A P28223 3/20 0.97
CYP1A2 P05177 3/20 0.97
OPRM1 P35372 3/20 0.97
ADRA2B P18089 2/20 0.97
CHRM1 P11229 2/20 0.97
HTR2C P28335 2/20 0.97
HTR2B P41595 2/20 0.97
CHRM5 P08912 1/20 0.97
CYP2C9 P11712 1/20 0.97
NFKB1 P19838 1/20 0.97
HTR6 P50406 1/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methapyrilene SCHEMBL19209 0.99 CYP2D6 (1.00) CYP2D6CHRM2ADRA2ADRD1SLC6A4
Methapyrilene SCHEMBL498484 0.97 KDM4E (1.00) CYP2D6CHRM2ADRA2ADRD1SLC6A4
Methapyrilene SCHEMBL1074644 0.96 CYP2D6 (0.95) CYP2D6CHRM2ADRA2ADRD1SLC6A4
Methapyrilene SCHEMBL28140755 0.91 CYP2D6 (0.86) CYP2D6CHRM2ADRA2ADRD1SLC6A4
Methapyrilene SCHEMBL7121305 0.91 CYP2D6 (0.86) CYP2D6CHRM2ADRA2ADRD1SLC6A4
Methapyrilene SCHEMBL4902232 0.88 CYP2D6 (0.80) CYP2D6CHRM2ADRA2ADRD1SLC6A4
SCHEMBL7297232 0.83 CYP2D6 (0.73) CYP2D6CHRM2ADRA2ADRD1SLC6A4
SCHEMBL10674626 0.81 CYP2D6 (0.70) CYP2D6CHRM2ADRA2ADRD1SLC6A4
SCHEMBL7311717 0.80 CYP2D6 (0.68) CYP2D6CHRM2ADRA2ADRD1SLC6A4
Methylpromazine SCHEMBL28086160 0.79 CYP2D6 (0.64) CYP2D6CHRM2ADRA2ADRD1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180155522-A1 COTTONSEED OIL BASED LIQUID COLOR COMPOSITION AND PLASTICS COLORING METHOD USING THE SAME MAGUIRE STEPHEN B (US) 2018-06-07 US claimed
US-11795297-B2 Plastics coloring using cottonseed oil-based liquid color compositions MAGUIRE STEPHEN B (US) 2023-10-24 US disclosed
EP-4139386-A1 PLASTICS COLORING USING COTTONSEED OIL-BASED LIQUID COLOR COMPOSITIONS Maguire, Stephen B. (US) 2023-03-01 EP disclosed
WO-2021217074-A1 PLASTICS COLORING COTTONSEED OIL-BASED LIQUID COLOR COMPOSITIONS MAGUIRE STEPHEN B (US) 2021-10-28 WO disclosed
US-10919206-B2 Cottonseed oil based liquid color composition and plastics coloring method using the same MAGUIRE STEPHEN B (US) 2021-02-16 US disclosed
US-10767031-B2 Cottonseed oil based liquid color composition and plastics coloring method using the same MAGUIRE STEPHEN B (US) 2020-09-08 US disclosed
US-20200247975-A1 PLASTICS COLORING USING COTTONSEED OIL-BASED LIQUID COLOR COMPOSITIONS . (JP) 2020-08-06 US disclosed
EP-2789074-B1 ELECTRICAL MACHINE FISHER & PAYKEL APPLIANCES LTD (NZ) 2020-04-01 EP disclosed
US-10597513-B2 Cottonseed oil based additive compositions for plastics molding and extrusion MAGUIRE STEPHEN B (US) 2020-03-24 US disclosed
US-20180155522-A1 COTTONSEED OIL BASED LIQUID COLOR COMPOSITION AND PLASTICS COLORING METHOD USING THE SAME MAGUIRE STEPHEN B (US) 2018-06-07 US disclosed
US-6663995-B2 End plates for a fuel cell stack structure GENERAL MOTORS CORPORATION 2003-12-16 US disclosed
WO-2003094267-A1 END PLATES FOR A FUEL CELL STACK STRUCTURE GENERAL MOTORS CORPORATION (US) 2003-11-13 WO disclosed
WO-2003094260-A1 COMPACT FUEL CELL STACK STRUCTURE GENERAL MOTORS CORPORATION (US) 2003-11-13 WO disclosed
WO-2003094275-A1 METHOD AND APPARATUS FOR PROVIDING A UNIFORM FUEL CELL STACK STRUCTURE GENERAL MOTORS CORPORATION (US) 2003-11-13 WO disclosed
US-20030203270-A1 END PLATES FOR A FUEL CELL STACK STRUCTURE GM Global Technology Operations LLC 2003-10-30 US disclosed
US-20030203268-A1 Compact fuel cell stack structure GM Global Technology Operations LLC 2003-10-30 US disclosed
US-20030203269-A1 Method and apparatus for providing a uniform fuel cell stack structure GM Global Technology Operations LLC 2003-10-30 US disclosed
EP-0726135-B1 VEHICLE RESIN-MADE SHOCK ABSORBING MEMBER IDEMITSU PETROCHEMICAL CO (JP) 2002-10-23 EP disclosed
US-5806591-A Rod guide SABLE DONALD E (US) 1998-09-15 US disclosed
US-5542711-A Device for fitting a hot element to a hollow body made of thermoplastic including at least one cold fluid inlet, and hollow body including such a device ORBEY PLASTIQUES AND INDUSTRIES (FR) 1996-08-06 US disclosed