Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL11798286 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Potassium Ion SCHEMBL11803005 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Stearyl Fumaric Acid SCHEMBL2431953 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Potassium Ion SCHEMBL11798639 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Potassium Ion SCHEMBL11798301 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Stearyl Fumaric Acid SCHEMBL2431940 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Potassium Ion SCHEMBL11798647 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Potassium Ion SCHEMBL11801795 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Stearyl Fumaric Acid SCHEMBL25396 | 0.96 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL9679071 | 0.96 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107106568-B | Pharmaceutical compositions of fused aminodihydrothiazine derivatives | 卫材R&D管理有限公司 | 2023-09-26 | — | — | CN | disclosed |
| EP-3205343-B1 | PHARMACEUTICAL COMPOSITION OF FUSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2022-01-26 | — | — | EP | disclosed |
| US-10117876-B2 | Pharmaceutical composition of fused aminodihydrothiazine derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-11-06 | — | — | US | disclosed |
| US-20180263998-A1 | PHARMACEUTICAL COMPOSITION OF FUSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-09-20 | — | — | US | disclosed |
| US-10076524-B1 | — | — | 2018-09-18 | — | — | US | disclosed |
| EP-3205343-A1 | PHARMACEUTICAL COMPOSITION OF FUSED AMINODIHYDROTHIAZINE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2017-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10076524-B1 | — | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP3A5, SLC10A1 | HCAR2 239/4885ATM 4794/4885MAPT 2491/4885 |
| US-20180263998-A1 | PHARMACEUTICAL COMPOSITION OF FUSED AMINODIHYDROTHIAZINE DERIVATIVE | CYP3A5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP7A1 | HCAR2 463/4885ATM 4444/4885MAPT 1125/4885 |
| US-10117876-B2 | Pharmaceutical composition of fused aminodihydrothiazine derivative | CYP3A5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP7A1 | HCAR2 463/4885ATM 4444/4885MAPT 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.