Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.41 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28698477 | 0.89 | BACE1 (0.47) | GRM5L3MBTL1LMNAALDH1A1MAPT | |
| SCHEMBL28673972 | 0.89 | LMNA (0.46) | L3MBTL1SMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL19212115 | 0.87 | GRM5 (0.51) | GRM5L3MBTL1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL19211018 | 0.83 | LMNA (0.41) | L3MBTL1SMN1; SMN2LMNAALDH1A1IDO1 | |
| SCHEMBL28931815 | 0.82 | LMNA (0.41) | L3MBTL1SMN1; SMN2LMNAIDO1HTT | |
| SCHEMBL19212126 | 0.80 | LMNA (0.40) | L3MBTL1SMN1; SMN2LMNAMAPTIDO1 | |
| SCHEMBL19210903 | 0.80 | GRM5 (0.50) | GRM5L3MBTL1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL19212112 | 0.79 | LMNA (0.44) | GRM5L3MBTL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL28697404 | 0.78 | ABCB1 (0.43) | L3MBTL1MAPT | |
| SCHEMBL21457808 | 0.78 | ABCB1 (0.42) | MAPTIDO1KMT2AUSP28USP25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |