Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | BCR | P11274 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735155 | 0.85 | PHGDH (0.50) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL20524606 | 0.82 | OPRK1 (0.41) | SMN1; SMN2ALDH1A1MAPTLMNAOPRK1 | |
| SCHEMBL27741480 | 0.82 | SMN1; SMN2 (0.46) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL18837988 | 0.80 | MEN1 (0.53) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL3075186 | 0.80 | CNR2 (0.47) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL27927939 | 0.80 | KMT2A (0.47) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL27927936 | 0.79 | ABL1 (0.44) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL29631786 | 0.79 | HSD11B1 (0.46) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL4098052 | 0.79 | KMT2A (0.44) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL1432330 | 0.79 | SMN1; SMN2 (0.72) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |