Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 14/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212256 | 0.82 | KMT2A (0.46) | OPRK1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL20524610 | 0.82 | SMO (0.38) | OPRK1ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL22712289 | 0.80 | KIT (0.47) | ALDH1A1HSD17B10KDM4ELMNAMAPT | |
| SCHEMBL30323218 | 0.80 | KIT (0.47) | ALDH1A1HSD17B10KDM4ELMNAMAPT | |
| SCHEMBL3435704 | 0.79 | ALDH1A1 (0.42) | OPRK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29631786 | 0.79 | HSD11B1 (0.46) | OPRK1ALDH1A1HSD17B10LMNAMAPT | |
| SCHEMBL29969981 | 0.78 | HRH4 (0.53) | SMN1; SMN2 | |
| SCHEMBL20605140 | 0.78 | HRH4 (0.53) | SMN1; SMN2 | |
| SCHEMBL13106057 | 0.78 | MDM2 (0.44) | OPRK1LMNA | |
| SCHEMBL2711135 | 0.78 | HTT (0.43) | OPRK1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600312-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | Takeda Pharmaceutical Company Limited (JP) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018183145-A1 | PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-04 | — | — | WO | disclosed |