Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.39 |
| ▸ | CDK9 | P50750 | 5/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957488 | 0.84 | PDK4 (0.52) | CCNT1CDK9JAK1 | |
| SCHEMBL19212389 | 0.83 | MEN1 (0.40) | CCNT1CDK9MMP2MMP3JAK1 | |
| SCHEMBL22324853 | 0.80 | L3MBTL1 (0.41) | MMP2MMP3JAK1MAPTNPC1 | |
| SCHEMBL4949255 | 0.80 | ALDH1A1 (0.46) | CCNT1CDK9MMP2MMP3MEN1 | |
| SCHEMBL23291429 | 0.78 | MAPT (0.49) | TRPV1MMP2MMP3MEN1KMT2A | |
| SCHEMBL8013522 | 0.78 | MAPT (0.39) | TRPV1MMP2MMP3MEN1KMT2A | |
| SCHEMBL5376595 | 0.77 | ALDH1A1 (0.48) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL22324799 | 0.75 | CPS1 (0.48) | CCNT1CDK9ALDH1A1 | |
| SCHEMBL22324862 | 0.74 | KCNH2 (0.45) | MEN1KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL15524420 | 0.74 | ADAM10 (0.43) | MEN1KMT2AMAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |