Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29707436 | 1.00 | BACE1 (0.44) | BACE1SMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL29707420 | 0.87 | L3MBTL1 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C19SMARCA2 | |
| SCHEMBL22957454 | 0.87 | L3MBTL1 (0.50) | SMN1; SMN2MEN1KMT2ACYP2C19SMARCA2 | |
| SCHEMBL29576917 | 0.87 | SMN1; SMN2 (0.48) | BACE1SMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL19211056 | 0.87 | SMN1; SMN2 (0.48) | BACE1SMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL28256705 | 0.83 | USP28 (0.35) | BACE1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL22957521 | 0.82 | KIT (0.48) | BACE1SMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL19212323 | 0.82 | MAPT (0.60) | SMN1; SMN2MEN1KMT2ACYP2C19LMNA | |
| SCHEMBL28688759 | 0.81 | PDE4D (0.44) | SMN1; SMN2MEN1KMT2ACYP2C19SMARCA2 | |
| SCHEMBL29129953 | 0.80 | GPR119 (0.54) | SMN1; SMN2MEN1KMT2ACYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |