Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212209 | 0.85 | GRM5 (0.43) | GRM5KDM5AKDM4CKDM5BOPRL1 | |
| SCHEMBL17397790 | 0.82 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL15778748 | 0.82 | SLC6A2 (0.46) | GRM5KDM5AKDM4CKDM5BOPRL1 | |
| SCHEMBL19212180 | 0.81 | GPR119 (0.51) | GRM5SMN1; SMN2HPGDTP53MAPT | |
| SCHEMBL29707348 | 0.81 | GPR119 (0.51) | GRM5SMN1; SMN2HPGDTP53MAPT | |
| SCHEMBL19212250 | 0.80 | GRM5 (0.44) | GRM5KDM5AKDM4CKDM5BOPRL1 | |
| SCHEMBL23291443 | 0.80 | GRM5 (0.42) | GRM5OPRL1SMN1; SMN2MAPTHTT | |
| SCHEMBL10088507 | 0.79 | SLC6A2 (0.44) | GRM5KDM5AKDM4CKDM5BOPRL1 | |
| SCHEMBL3900326 | 0.77 | NUDT1 (0.43) | SLC6A2SLC6A4SLC6A3CYP2C9 | |
| SCHEMBL17596063 | 0.77 | DRD2 (0.50) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |