Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15228262 | 0.84 | ERCC1 (0.44) | KMT2ATDP1SMN1; SMN2ERCC1ERCC4 | |
| SCHEMBL3844258 | 0.77 | ERCC1 (0.50) | KMT2ATDP1PKMERCC1ERCC4 | |
| SCHEMBL17546137 | 0.76 | ERCC1 (0.52) | PKMSMN1; SMN2ERCC1ERCC4GABRA1 | |
| SCHEMBL15816623 | 0.75 | ALDH1A1 (0.55) | KMT2ASMN1; SMN2ERCC1ERCC4GABRA1 | |
| SCHEMBL13729262 | 0.75 | CREBBP (0.47) | KMT2APKMERCC1ERCC4MEN1 | |
| SCHEMBL2635821 | 0.75 | ERCC1 (0.41) | KMT2ATDP1SMN1; SMN2ERCC1ERCC4 | |
| SCHEMBL5184688 | 0.74 | KDM4E (0.47) | KMT2ATDP1PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL20772934 | 0.73 | KMT2A (0.47) | KMT2ATDP1PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL31053271 | 0.73 | KMT2A (0.47) | KMT2ATDP1PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL6024765 | 0.73 | MAPT (0.44) | KMT2ATDP1PKMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328869-A2 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010037054-A2 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010037059-A2 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-04-01 | — | — | WO | disclosed |