Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691121 | 0.96 | MAPK1 (0.40) | SMN1; SMN2MAPK1KMT2AMEN1KDM4E | |
| SCHEMBL23135868 | 0.94 | MAPK1 (0.39) | SMN1; SMN2MAPK1KMT2AMEN1KDM4E | |
| SCHEMBL16900591 | 0.92 | MAPK1 (0.41) | SMN1; SMN2MAPK1KMT2AMEN1KDM4E | |
| SCHEMBL19216523 | 0.86 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPK1KMT2AMEN1KDM4E | |
| SCHEMBL15106626 | 0.84 | MAPK1 (0.37) | SMN1; SMN2MAPK1KMT2AMEN1KDM4E | |
| SCHEMBL13269316 | 0.84 | OPRM1 (0.48) | MAPK1KMT2AMEN1KDM4EPOLB | |
| SCHEMBL19601350 | 0.84 | MAPK1 (0.37) | SMN1; SMN2MAPK1KMT2AMEN1KDM4E | |
| SCHEMBL23135867 | 0.84 | TSHR (0.43) | MAPK1KMT2AMEN1KDM4EPOLB | |
| SCHEMBL25477600 | 0.84 | CYP4F2 (0.39) | CYP4F2CYP4A11 | |
| SCHEMBL12597835 | 0.83 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPK1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795146-B | Isoxazole derivatives as inhibitors of mutant isocitrate dehydrogenase 1 | 第一三共株式会社 | 2020-06-26 | — | — | CN | disclosed |
| US-10040791-B2 | Isoxazole derivative as mutant isocitrate dehydrogenase 1 inhibitor | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-08-07 | — | — | US | disclosed |
| US-20170313696-A1 | ISOXAZOLE DERIVATIVE AS MUTANT ISOCITRATE DEHYDROGENASE 1 INHIBITOR | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-11-02 | — | — | US | disclosed |
| EP-3202766-A1 | ISOXAZOLE DERIVATIVE AS MUTATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313696-A1 | ISOXAZOLE DERIVATIVE AS MUTANT ISOCITRATE DEHYDROGENASE 1 INHIBITOR | IDH1, IDH3A, IDH3B | SMN1; SMN2 2777/4885MAPK1 942/4885KMT2A 202/4885 |
| US-10040791-B2 | Isoxazole derivative as mutant isocitrate dehydrogenase 1 inhibitor | IDH1, IDH3A, IDH3B | SMN1; SMN2 2777/4885MAPK1 942/4885KMT2A 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.