Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.31 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.31 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 4/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19220306 | 1.00 | DRD3 (0.35) | DRD3KDM4EALDH1A1HPGDKEAP1 | |
| SCHEMBL19220268 | 1.00 | DRD3 (0.35) | DRD3KDM4EALDH1A1HPGDKEAP1 | |
| SCHEMBL19220307 | 1.00 | DRD3 (0.35) | DRD3KDM4EALDH1A1HPGDKEAP1 | |
| SCHEMBL19220270 | 1.00 | DRD3 (0.35) | DRD3KDM4EALDH1A1HPGDKEAP1 | |
| SCHEMBL19220293 | 0.87 | DRD3 (0.35) | DRD3KDM4EKEAP1NFE2L2BCHE | |
| SCHEMBL19223284 | 0.87 | DRD3 (0.35) | DRD3KDM4EKEAP1NFE2L2BCHE | |
| SCHEMBL19220266 | 0.87 | DRD3 (0.35) | DRD3KDM4EKEAP1NFE2L2BCHE | |
| SCHEMBL19220265 | 0.85 | MTNR1A (0.37) | HPGDFAAH | |
| SCHEMBL19220269 | 0.85 | NAAA (0.36) | DRD3KDM4EALDH1A1HPGDKEAP1 | |
| SCHEMBL26878452 | 0.85 | MTNR1A (0.37) | HPGDFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226146-A1 | PROCESS FOR MAKING CHLORO-SUBSTITUTED NUCLEOSIDE PHOSPHORAMIDATE COMPOUNDS | MERCK SHARP & DOHME LLC | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226146-A1 | PROCESS FOR MAKING CHLORO-SUBSTITUTED NUCLEOSIDE PHOSPHORAMIDATE COMPOUNDS | NUDT1, PNP, SAMHD1 | DRD3 3683/4885KDM4E 3673/4885ALDH1A1 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.