Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.38 |
| ▸ | LTA4H | P09960 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927872 | 0.84 | SIGMAR1 (0.35) | SIGMAR1LTA4H | |
| SCHEMBL6925405 | 0.83 | SIGMAR1 (0.51) | SIGMAR1LTA4H | |
| SCHEMBL16768498 | 0.81 | P2RY1 (0.39) | SIGMAR1LTA4HP2RX7 | |
| SCHEMBL18993991 | 0.78 | LTA4H (0.39) | SIGMAR1LTA4HKCNH2EGLN1S1PR1 | |
| SCHEMBL8014729 | 0.77 | S1PR5 (0.44) | SIGMAR1KCNH2S1PR1S1PR3S1PR5 | |
| SCHEMBL744980 | 0.75 | ALDH1A1 (0.36) | LTA4HP2RX7 | |
| SCHEMBL23508675 | 0.71 | GRM4 (0.38) | SIGMAR1LTA4HP2RX7 | |
| SCHEMBL3245781 | 0.69 | AVPR1A (0.50) | KCNH2 | |
| SCHEMBL13368621 | 0.69 | KCNH2 (0.62) | SIGMAR1KCNH2EGLN1 | |
| SCHEMBL31149376 | 0.69 | P2RX7 (0.37) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864331-B1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | BRISTOL MYERS SQUIBB CO (US) | 2017-08-09 | — | — | EP | disclosed |