Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415668 | 0.76 | EED (0.33) | TDP1 | |
| SCHEMBL1922494 | 0.75 | — | — | |
| SCHEMBL1922193 | 0.74 | APLNR (0.35) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL16013129 | 0.71 | TDP1 (0.35) | ALDH1A1CYP1A2CYP3A4ALOX15HSD17B10 | |
| SCHEMBL3408682 | 0.69 | IDO1 (0.46) | ALDH1A1POLB | |
| SCHEMBL3411354 | 0.65 | — | — | |
| SCHEMBL722683 | 0.64 | IDO1 (0.49) | ALDH1A1MAOA | |
| SCHEMBL19582889 | 0.63 | MBOAT4 (0.33) | MAOA | |
| SCHEMBL22588550 | 0.63 | APLNR (0.47) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL481256 | 0.63 | IDO1 (0.42) | ALDH1A1HPGDMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044047-B2 | 5-substituted benzoxazines | HOFFMAN-LA ROCHE INC. (US) | 2011-10-25 | — | — | US | disclosed |
| EP-2328881-A1 | 5-SUBSTITUTED BENZOXAZINES | F. Hoffmann-La Roche AG (CH) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010026112-A1 | 5-SUBSTITUTED BENZOXAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| US-20100063042-A1 | 5-SUBSTITUTED BENZOXAZINES | HOFFMANN-LA ROCHE, INC. | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063042-A1 | 5-SUBSTITUTED BENZOXAZINES | HTR5A, NPY5R, GABRA5 | ALDH1A1 1885/4885ABCB11 761/4885NR3C1 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.