Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19369013 | 0.80 | LMNA (0.33) | NPC1LMNA | |
| SCHEMBL19225915 | 0.77 | — | — | |
| SCHEMBL2197540 | 0.77 | RAB9A (0.35) | RAB9ASMN1; SMN2DUSP3L3MBTL1NPC1 | |
| SCHEMBL19696738 | 0.70 | — | — | |
| SCHEMBL24828273 | 0.70 | — | — | |
| SCHEMBL19629545 | 0.68 | — | — | |
| SCHEMBL20940174 | 0.67 | — | — | |
| SCHEMBL24747882 | 0.67 | SMN1; SMN2 (0.36) | RAB9ASMN1; SMN2DUSP3L3MBTL1NPC1 | |
| SCHEMBL26677728 | 0.66 | DGAT1 (0.36) | RAB9ASMN1; SMN2DUSP3L3MBTL1NPC1 | |
| SCHEMBL19879851 | 0.65 | PTGER1 (0.32) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796726-B2 | Dihydroquinoline pyrazolyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170226116-A1 | NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226116-A1 | NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS | RECQL, NDUFS5, NDUFS7 | RAB9A 262/4885SMN1; SMN2 2956/4885DUSP3 4428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.