Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922551 | 0.88 | GPR119 (0.44) | TSHRMAPTGPR119ALDH1A1TEAD1 | |
| SCHEMBL1295724 | 0.86 | GPR119 (0.62) | GPR119 | |
| SCHEMBL1922555 | 0.82 | GPR119 (0.48) | GPR119TEAD1TEAD3CYP4F2CYP4A11 | |
| SCHEMBL1839393 | 0.79 | GPR119 (0.46) | GPR119TEAD1TEAD3NPC1RAB9A | |
| SCHEMBL2431556 | 0.79 | GPR119 (0.63) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL1296010 | 0.75 | GPR119 (0.61) | GPR119 | |
| SCHEMBL1841877 | 0.75 | GPR119 (0.47) | GPR119 | |
| SCHEMBL4400790 | 0.75 | MAOA (0.40) | TSHRMAPTGPR119ALDH1A1TEAD1 | |
| SCHEMBL15262239 | 0.75 | ALDH1A1 (0.47) | TSHRMAPTTP53MAPK1ALDH1A1 | |
| SCHEMBL26619790 | 0.75 | MEN1 (0.42) | GPR119ALDH1A1TEAD1TEAD3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328867-A1 | HETEROCYCLIC GPCR AGONISTS | Prosidion Limited (GB) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010004347-A1 | HETEROCYCLIC GPCR AGONISTS | PROSIDION LIMITED (GB) | 2010-01-14 | — | — | WO | disclosed |