Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NMT2 | O60551 | 1/20 | 0.44 |
| ▸ | NMT1 | P30419 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19230819 | 0.85 | GRM5 (0.42) | MAOBRAB9AALDH1A1NPC1NFKB1 | |
| SCHEMBL31193929 | 0.83 | KDM4E (0.55) | KDM4ENPSR1RAB9AL3MBTL1TSHR | |
| SCHEMBL4126156 | 0.81 | POLB (0.53) | KDM4EMEN1HSP90AA1KMT2AGABRA5 | |
| SCHEMBL6380407 | 0.81 | KDM4E (0.56) | KDM4ENPSR1TSHRALDH1A1NFKB1 | |
| SCHEMBL19230699 | 0.81 | PKM (0.42) | MAOBL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6377043 | 0.76 | KDM4E (0.59) | KDM4EMEN1KMT2ANPSR1TSHR | |
| SCHEMBL26641047 | 0.75 | MAPT (0.46) | KDM4EMEN1KMT2AGABRA5NPSR1 | |
| SCHEMBL5077233 | 0.75 | KDM4E (0.58) | KDM4EMEN1HSP90AA1KMT2ANPSR1 | |
| SCHEMBL4192553 | 0.75 | KDM4E (0.58) | KDM4ENPSR1RAB9ATSHRALDH1A1 | |
| SCHEMBL474055 | 0.74 | KDM4E (0.57) | KDM4ENPSR1TSHRP2RY12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602811-B | FXR receptor agonists | 轩竹生物科技有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-108602811-A | FXR receptor stimulating agents | 山东轩竹医药科技有限公司 | 2018-09-28 | — | — | CN | disclosed |
| WO-2017133521-A1 | FXR RECEPTOR AGONIST | 山东轩竹医药科技有限公司 | 2017-08-10 | — | — | WO | disclosed |