Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.50 |
| ▸ | CFD | P00746 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19234012 | 0.79 | MC4R (0.57) | HTR2CCACNA1G | |
| SCHEMBL19234280 | 0.78 | CFD (0.46) | CFDHTR2C | |
| SCHEMBL19233887 | 0.76 | CFD (0.49) | CFD | |
| SCHEMBL13647056 | 0.75 | MAPK14 (0.63) | SCN9AHTR2CMAPK14ROCK2ROCK1 | |
| SCHEMBL19234386 | 0.74 | F2 (0.42) | CFDCHRM3KITCNR1 | |
| SCHEMBL29418710 | 0.73 | HPGD (0.63) | SCN9ACFDHTR2CMAPK14ROCK2 | |
| SCHEMBL20477566 | 0.73 | HPGD (0.63) | SCN9ACFDHTR2CMAPK14ROCK2 | |
| SCHEMBL20477540 | 0.73 | HPGD (0.63) | SCN9ACFDHTR2CMAPK14ROCK2 | |
| SCHEMBL29418763 | 0.73 | HPGD (0.63) | SCN9ACFDHTR2CMAPK14ROCK2 | |
| SCHEMBL4575965 | 0.73 | MAPK14 (0.60) | SCN9AHTR2CMAPK14ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |