Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30772030 | 0.86 | CTSC (0.46) | CFDMCHR1METAP2METAP1DPP4 | |
| SCHEMBL19234012 | 0.84 | MC4R (0.57) | DPP8DPP9DPP7DPP4F2 | |
| SCHEMBL19233889 | 0.81 | P2RX7 (0.48) | CFDDPP8DPP9DPP7F2 | |
| SCHEMBL19233943 | 0.78 | SCN9A (0.50) | CFDHTR2C | |
| SCHEMBL19233887 | 0.77 | CFD (0.49) | CFDDPP8DPP9DPP7DPP4 | |
| SCHEMBL19234311 | 0.75 | GID4 (0.44) | CFDDPP8DPP9DPP7 | |
| SCHEMBL19234386 | 0.73 | F2 (0.42) | CFDF2 | |
| SCHEMBL8083501 | 0.72 | ERCC1 (0.65) | METAP2METAP1NR1H4 | |
| SCHEMBL6564062 | 0.71 | IDO1 (0.55) | METAP2METAP1TPSAB1IDO1NLN | |
| SCHEMBL19234388 | 0.71 | P2RX7 (0.47) | CFDDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |