Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 5/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12480776 | 0.80 | CHRNB4 (0.42) | CHRNB4CHRNA3TACR1HTR2CKCNH2 | |
| SCHEMBL12480778 | 0.80 | CHRNB4 (0.42) | CHRNB4CHRNA3TACR1HTR2CKCNH2 | |
| SCHEMBL19234029 | 0.78 | HTR1A (0.43) | KCNH2CYP2D6HTR1AHTR2AHRH1 | |
| SCHEMBL19234428 | 0.78 | IDO1 (0.42) | CHRNB4CHRNA3 | |
| SCHEMBL19234330 | 0.75 | HTR6 (0.48) | HTR2CHTR6 | |
| SCHEMBL25313136 | 0.74 | TACR1 (0.41) | CHRNB4CHRNA3TACR1HTR2CKCNH2 | |
| SCHEMBL25314944 | 0.74 | TACR1 (0.41) | CHRNB4CHRNA3TACR1HTR2CKCNH2 | |
| SCHEMBL4206172 | 0.70 | CHRNB2 (0.45) | CHRNB4CHRNA3 | |
| SCHEMBL4206176 | 0.70 | CHRNB2 (0.45) | CHRNB4CHRNA3 | |
| SCHEMBL11448286 | 0.68 | CHRNB4 (0.46) | CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |