Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3197903 | 0.87 | CA1 (0.49) | MEN1KMT2AKDM4ELMNACYP2C9 | |
| SCHEMBL614551 | 0.80 | LMNA (0.54) | MEN1KMT2AKDM4ELMNACYP2C9 | |
| SCHEMBL9248550 | 0.80 | MEN1 (0.57) | MEN1KMT2AKDM4ELMNACYP2C9 | |
| SCHEMBL3896042 | 0.78 | ALOX15 (0.67) | ALOX15 | |
| SCHEMBL4333071 | 0.77 | GPR17 (0.58) | MEN1KMT2AKDM4ELMNACYP2C9 | |
| SCHEMBL28207427 | 0.76 | KDM4E (0.50) | MEN1KMT2AKDM4ELMNACYP2C9 | |
| SCHEMBL6218634 | 0.76 | PIN1 (0.48) | — | |
| SCHEMBL349187 | 0.75 | PARP1 (0.49) | KMT2AKDM4EHPGDPARP1 | |
| SCHEMBL9690283 | 0.75 | KDM4E (0.62) | MEN1KMT2AKDM4ELMNAHPGD | |
| SCHEMBL8139112 | 0.74 | MEN1 (0.70) | MEN1KMT2AGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874777-B1 | 1H-PYRIMIDO[4,5-B]INDOLE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2011-06-08 | — | — | EP | disclosed |