Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 9/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19208522 | 0.90 | GPR119 (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL29781770 | 0.88 | SLC2A1 (0.40) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL19208780 | 0.88 | SLC2A1 (0.40) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL19236963 | 0.87 | PSEN1 (0.42) | ALDH1A1KMT2ALMNASLC2A1PSEN1 | |
| SCHEMBL24920126 | 0.79 | KDM4E (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL13844068 | 0.72 | DYRK1A (0.47) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12678074 | 0.72 | ALDH1A1 (0.43) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19208841 | 0.72 | TDP1 (0.44) | KDM4EALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL29781573 | 0.71 | CFD (0.46) | CFD | |
| SCHEMBL19208651 | 0.71 | CFD (0.46) | CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11559515-B2 | Indole compounds and analogues thereof | BIOCRYST PHARMACEUTICALS, INC. (US) | 2023-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11559515-B2 | Indole compounds and analogues thereof | C5, IDO1, IDO2 | DYRK1A 3052/4885KDM4E 3768/4885ALDH1A1 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.