Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL752502 | 0.89 | GAA (0.72) | PKMLMNAALDH1A1GAAHTT | |
| SCHEMBL752501 | 0.84 | LMNA (0.88) | PKMLMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL752687 | 0.80 | NPC1 (0.67) | PKMALDH1A1GAANPC1RAB9A | |
| SCHEMBL5735336 | 0.77 | GRM5 (0.64) | PKMLMNARAB9AKMT2A | |
| SCHEMBL20323444 | 0.77 | YAP1 (0.84) | PKMALDH1A1GAAHTTPOLB | |
| SCHEMBL7894190 | 0.76 | PKM (0.76) | PKMLMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL752503 | 0.76 | PKM (0.69) | PKMLMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5063837 | 0.76 | GRM5 (0.64) | LMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL28700737 | 0.75 | LMNA (0.69) | PKMLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7890108 | 0.75 | LMNA (0.79) | PKMLMNAALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170234881-A1 | METHODS OF DIAGNOSING AND TREATING CANCER | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-08-17 | — | — | US | disclosed |
| US-20170234881-A1 | METHODS OF DIAGNOSING AND TREATING CANCER | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-08-17 | — | — | US | disclosed |