Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19239020 | 0.89 | TSHR (0.61) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL763799 | 0.85 | HSD11B1 (0.53) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL751898 | 0.85 | HSD11B1 (0.53) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL751771 | 0.80 | HSD11B1 (0.54) | HSD11B1ALDH1A1 | |
| SCHEMBL752526 | 0.80 | POLB (0.62) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL754186 | 0.78 | ACHE (0.58) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL15249010 | 0.72 | HSD11B1 (0.61) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL762993 | 0.72 | ALDH1A1 (0.51) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL751891 | 0.72 | ALDH1A1 (0.51) | POLBLMNAGAAKMT2AMEN1 | |
| SCHEMBL752834 | 0.71 | LMNA (0.63) | POLBLMNAGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170234881-A1 | METHODS OF DIAGNOSING AND TREATING CANCER | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-08-17 | — | — | US | disclosed |
| US-20170234881-A1 | METHODS OF DIAGNOSING AND TREATING CANCER | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-08-17 | — | — | US | disclosed |