Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925038 | 0.90 | ROCK2 (0.46) | MEN1KMT2AKDRPDGFRBMAPT | |
| SCHEMBL1923912 | 0.89 | KDR (0.48) | KDM4EPOLBSTING1MEN1KMT2A | |
| SCHEMBL1925334 | 0.88 | EPHX2 (0.48) | STING1CA12CA1CA2CA9 | |
| SCHEMBL1925337 | 0.88 | PKM (0.47) | ALDH1A1KDM4EPOLBPKMCA12 | |
| SCHEMBL1925039 | 0.86 | RIPK1 (0.44) | CA12CA1CA2CA9HTT | |
| SCHEMBL1926602 | 0.86 | KDM4E (0.46) | KDM4EPOLBPKMCA12CA1 | |
| SCHEMBL1924884 | 0.86 | MEN1 (0.42) | POLBCA12CA1CA2CA9 | |
| SCHEMBL1925482 | 0.86 | STING1 (0.44) | ALDH1A1KDM4EPOLBSTING1HTT | |
| SCHEMBL1924602 | 0.86 | EPHX2 (0.49) | PKMSTING1HTTMEN1KMT2A | |
| SCHEMBL1926895 | 0.86 | MAPT (0.41) | KDM4EPOLBHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |