Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | GOT1 | P17174 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923967 | 0.90 | MEN1 (0.51) | EPHX2GOT1MAPTKDRMEN1 | |
| SCHEMBL1925178 | 0.90 | KDR (0.49) | CA12CA1CA2CA9KDR | |
| SCHEMBL1925039 | 0.90 | RIPK1 (0.44) | EPHX2GOT1CA12CA1CA2 | |
| SCHEMBL1925429 | 0.89 | RIPK1 (0.46) | CA12CA1CA2MAPTCA9 | |
| SCHEMBL1924464 | 0.88 | ALDH1A1 (0.38) | CA12CA1CA2MAPTCA9 | |
| SCHEMBL1924602 | 0.87 | EPHX2 (0.49) | EPHX2GOT1FFAR1MAPTSTING1 | |
| SCHEMBL1924020 | 0.86 | CDK8 (0.43) | KDR | |
| SCHEMBL1924459 | 0.86 | KDM4E (0.46) | MAPTKDRMEN1KMT2ADGAT1 | |
| SCHEMBL1923912 | 0.86 | KDR (0.48) | KIF11FFAR1MAPTSTING1KDR | |
| SCHEMBL1924893 | 0.86 | KDR (0.51) | CA1CA2CA9KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |