Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | BLK | P51451 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923912 | 0.89 | KDR (0.48) | AKT2KDRSTING1PDGFRBSMN1; SMN2 | |
| SCHEMBL1924884 | 0.89 | MEN1 (0.42) | AKT2KDRLCKBLKROCK2 | |
| SCHEMBL1924795 | 0.89 | CDK8 (0.44) | AKT2KDRRETCDK8PDGFRB | |
| SCHEMBL1924534 | 0.88 | AURKA (0.44) | AKT2KDRLCKBLKPDGFRB | |
| SCHEMBL1924620 | 0.88 | CSF1R (0.53) | KDRLCKBLKROCK2MAP4K4 | |
| SCHEMBL1924361 | 0.86 | KMT2A (0.46) | ROCK2ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL1925746 | 0.86 | ITGB1 (0.52) | KDRALDH1A1PDGFRBSMN1; SMN2MEN1 | |
| SCHEMBL1924464 | 0.85 | ALDH1A1 (0.38) | AKT2KDRSTING1ALDH1A1PDGFRB | |
| SCHEMBL1926602 | 0.84 | KDM4E (0.46) | KDRROCK2PDGFRBSMN1; SMN2MEN1 | |
| SCHEMBL1925038 | 0.84 | ROCK2 (0.46) | KDRLCKBLKROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856043-B1 | 1-H-PYRROLE-2-CARBOXAMIDES AND IMIDAZOLE-5-CARBOXAMIDES AND USE THEREOF AS FAK, KDR AND TIE2 KINASE MODULATORS FOR THE TREATMENT OF CANCER | AVENTIS PHARMA SA (FR) | 2011-06-08 | — | — | EP | claimed |