Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | LPL | P06858 | 7/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15288409 | 0.85 | MKNK1 (0.46) | FLT3LPLLIPGMKNK1MKNK2 | |
| SCHEMBL20600818 | 0.81 | LPL (0.39) | LPLLIPGDGAT1FFAR1IRAK4 | |
| SCHEMBL18041611 | 0.77 | LPL (0.44) | LPLLIPGDGAT1FFAR1IRAK4 | |
| SCHEMBL24920098 | 0.76 | IRAK4 (0.33) | FFAR1IRAK4 | |
| SCHEMBL18005093 | 0.74 | TGFBR1 (0.41) | PIK3CA | |
| SCHEMBL2735666 | 0.74 | NPC1 (0.59) | LPLLIPG | |
| SCHEMBL25322090 | 0.73 | PIK3CA (0.38) | FLT3LPLLIPGPIK3CAMTOR | |
| SCHEMBL18041526 | 0.73 | TGFBR1 (0.42) | LPLLIPGDGAT1FFAR1 | |
| SCHEMBL24920081 | 0.72 | — | — | |
| SCHEMBL4470995 | 0.72 | LIPG (0.71) | LPLLIPGHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831079-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2017-08-16 | — | — | EP | disclosed |