Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19245876 | 0.83 | PDE5A (0.43) | SMN1; SMN2LMNAPOLBMAPK1TNF | |
| SCHEMBL18819578 | 0.83 | PDE5A (0.43) | SMN1; SMN2LMNAPOLBMAPK1TNF | |
| SCHEMBL18819577 | 0.83 | LMNA (0.35) | SMN1; SMN2LMNAPOLBMAPK1TNF | |
| SCHEMBL17682293 | 0.82 | ADORA2B (0.52) | SMN1; SMN2LMNAPOLBTNFPDE4A | |
| SCHEMBL19246013 | 0.78 | PDE5A (0.48) | SMN1; SMN2LMNAPOLBMAPK1TNF | |
| SCHEMBL13695581 | 0.72 | TNF (0.47) | SMN1; SMN2LMNAPOLBMAPK1TNF | |
| SCHEMBL24611635 | 0.70 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAPOLBMAPK1TNF | |
| SCHEMBL19245873 | 0.68 | PDE5A (0.46) | SMN1; SMN2LMNAPOLBMAPK1KDM4E | |
| SCHEMBL18819466 | 0.67 | TRPA1 (0.45) | SMN1; SMN2LMNAPOLBMAPK1TNF | |
| SCHEMBL17682258 | 0.67 | ADORA2B (0.56) | SMN1; SMN2LMNAPOLBTNFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205652-A1 | HYDROXYL PURINE COMPOUNDS AND APPLICATIONS THEREOF | Medshine Discovery Inc. (CN) | 2017-08-16 | — | — | EP | disclosed |