Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.82 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.50 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27654460 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL1924598 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL27634187 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 | |
| Maleic Acid SCHEMBL15660586 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3TDP1 | |
| Maleic Acid SCHEMBL2046430 | 0.91 | TSHR (1.00) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL1331192 | 0.91 | — | — | |
| Fumaric Acid SCHEMBL6875 | 0.91 | TSHR (1.00) | TSHRTP53EGLN1EGLN3TDP1 | |
| Maleic Acid SCHEMBL20487516 | 0.91 | TSHR (1.00) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL3998225 | 0.91 | — | — | |
| Fumaric Acid SCHEMBL650322 | 0.91 | TSHR (1.00) | TSHRTP53EGLN1EGLN3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112262847-A | Agent for inhibiting germination of wheat ears | 信阳农林学院 | 2021-01-26 | — | — | CN | claimed |
| CN-102124943-A | Method for producing hybrid cotton seeds by inducing male sterility of cotton with chemical male gametocide | JIANGSU KETENG COTTON CO LTD | 2011-07-20 | — | — | CN | claimed |
| CN-1829683-A | Mildronate, preparation method thereof and pharmaceutical composition based on mildronate | GRINDEKS JSC (LV) | 2006-09-06 | — | — | CN | claimed |
| JP-8151412-A | — | — | None | — | — | JP | disclosed |
| WO-2025079303-A1 | PLATING FILM FOR METAL SINTERING BONDING, METHOD FOR MANUFACTURING SAME, AND SEMICONDUCTOR MOUNTING SUBSTRATE | 奥野製薬工業株式会社 | 2025-04-17 | — | — | WO | disclosed |
| CN-108308019-B | Chemical male-killing hybrid seed production method for cotton suitable for production and application | 江苏省农业科学院 | 2021-03-12 | — | — | CN | disclosed |
| CN-112262847-A | Agent for inhibiting germination of wheat ears | 信阳农林学院 | 2021-01-26 | — | — | CN | disclosed |
| CN-112262847-A | Agent for inhibiting germination of wheat ears | 信阳农林学院 | 2021-01-26 | — | — | CN | disclosed |
| CN-110896751-A | Method for relieving high-temperature heat damage of summer corn | 安徽农业大学 | 2020-03-24 | — | — | CN | disclosed |
| CN-110896751-A | Method for relieving high-temperature heat damage of summer corn | 安徽农业大学 | 2020-03-24 | — | — | CN | disclosed |
| CN-110402259-A | Nitrile group-containing copolymer rubber | ZEON CORP | 2019-11-01 | — | — | CN | disclosed |
| US-5607912-A | Hydrochlorofluorocarbon azeotropic or azeotropic-like mixture | ASAHI GLASS COMPANY LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| JP-H08151412-A | METHOD FOR WATER-PROOFING POLYVINYL ALCOHOL RESIN | UNITIKA CHEM KK | 1996-06-11 | — | — | JP | disclosed |
| EP-0381216-B1 | Hydrochlorofluorocarbon azeotropic or azeotropic-like mixture | ASAHI GLASS CO LTD (JP) | 1995-12-27 | — | — | EP | disclosed |
| US-5364460-A | Gold and metal sulfite, reducing agent and organophosphonate; lemon yellow tone; corrosion resistance; nonspreading | C. UYEMURA & CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0618308-A1 | Electroless gold plating bath | C. UYEMURA & CO, LTD (JP) | 1994-10-05 | — | — | EP | disclosed |
| EP-0618307-A1 | Electroless gold plating bath | C. UYEMURA & CO, LTD (JP) | 1994-10-05 | — | — | EP | disclosed |
| WO-1990008814-A1 | HYDROCHLOROFLUOROCARBON AZEOTROPIC OR AZEOTROPIC-LIKE MIXTURE | ASAHI GLASS COMPANY LTD. (JP) | 1990-08-09 | — | — | WO | disclosed |
| EP-0381216-A1 | Hydrochlorofluorocarbon azeotropic or azeotropic-like mixture | ASAHI GLASS COMPANY LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |
| US-4356275-A | Aminoplast foams | BAYER AKTIENGESELLSCHAFT (DE) | 1982-10-26 | — | — | US | disclosed |