Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 15/20 | 1.00 |
| ▸ | IDO1 | P14902 | 8/20 | 0.61 |
| ▸ | MET | P08581 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249005 | 0.89 | TDO2 (1.00) | TDO2IDO1METKCNH2 | |
| SCHEMBL19249092 | 0.83 | TDO2 (1.00) | TDO2IDO1 | |
| SCHEMBL19249008 | 0.80 | TDO2 (0.74) | TDO2IDO1 | |
| SCHEMBL19249225 | 0.80 | TDO2 (1.00) | TDO2IDO1MET | |
| SCHEMBL19249224 | 0.78 | TDO2 (1.00) | TDO2IDO1MET | |
| SCHEMBL19249010 | 0.78 | TDO2 (0.64) | TDO2IDO1METKCNH2 | |
| SCHEMBL28673206 | 0.74 | TDO2 (0.81) | TDO2IDO1CYP1A2 | |
| SCHEMBL19249001 | 0.74 | TDO2 (0.81) | TDO2IDO1 | |
| SCHEMBL19248990 | 0.73 | TDO2 (0.72) | TDO2IDO1 | |
| SCHEMBL15230114 | 0.73 | METAP2 (0.70) | TDO2CYP1A2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133258-A1 | 1H-INDAZOLE DERIVATIVE AND USE THEREOF AS IDO INHIBITOR | 西华大学 | 2017-08-10 | — | — | WO | disclosed |