Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.48 |
| ▸ | RXRB | P28702 | 8/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 6/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19248989 | 0.87 | MRGPRX4 (0.53) | FOLH1IDO1TDO2MRGPRX4HPGD | |
| SCHEMBL19249081 | 0.87 | MAPT (0.46) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17440928 | 0.81 | MAOB (0.45) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19248986 | 0.78 | CCR5 (0.48) | IDO1TDO2MRGPRX4NPC1RAB9A | |
| SCHEMBL19249343 | 0.76 | TDO2 (0.74) | IDO1TDO2 | |
| SCHEMBL17440906 | 0.72 | IDO1 (0.51) | IDO1TDO2 | |
| SCHEMBL19248997 | 0.72 | NPC1 (0.52) | IDO1TDO2HPGDNPC1RAB9A | |
| SCHEMBL29151981 | 0.71 | RXRA (0.49) | RXRARXRBFOLH1MRGPRX4HPGD | |
| SCHEMBL30631225 | 0.71 | RXRA (0.49) | RXRARXRBFOLH1MRGPRX4HPGD | |
| SCHEMBL19249080 | 0.71 | IDO1 (0.51) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133258-A1 | 1H-INDAZOLE DERIVATIVE AND USE THEREOF AS IDO INHIBITOR | 西华大学 | 2017-08-10 | — | — | WO | disclosed |