Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19249657 | 0.80 | PTGS1 (0.45) | PTGS2PTGS1LMNASMN1; SMN2LOXL2 | |
| SCHEMBL19249472 | 0.76 | PTGS1 (0.45) | PTGS2PTGS1LMNASMN1; SMN2MAPT | |
| SCHEMBL19212556 | 0.74 | PTGS2 (0.46) | PTGS2PTGS1LMNAMAPTALDH1A1 | |
| SCHEMBL19249403 | 0.73 | PTGS1 (0.38) | PTGS2PTGS1LMNASMN1; SMN2LOXL2 | |
| SCHEMBL29595303 | 0.72 | MAPT (0.52) | PTGS2PTGS1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL19249695 | 0.72 | MAPT (0.52) | PTGS2PTGS1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL20915459 | 0.69 | LOXL2 (0.54) | LOXL2 | |
| SCHEMBL19249661 | 0.69 | LOXL2 (0.54) | LOXL2 | |
| SCHEMBL19212538 | 0.68 | NPC1 (0.36) | LMNASMN1; SMN2LOXL2ALDH1A1RAB9A | |
| SCHEMBL20489234 | 0.68 | LMNA (0.56) | LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017136871-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2017-08-17 | — | — | WO | disclosed |