Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 13/20 | 0.52 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890101 | 0.85 | OGA (0.55) | OGADHFRGPR119 | |
| SCHEMBL10530529 | 0.81 | LMNA (0.53) | OGA | |
| SCHEMBL83122 | 0.79 | OGA (0.50) | OGADHFRGPR119 | |
| SCHEMBL81909 | 0.75 | HRH4 (0.51) | OGADHFRHDAC3HDAC1HDAC2 | |
| SCHEMBL436107 | 0.74 | POLB (0.47) | OGADHFRGPR119 | |
| SCHEMBL12457554 | 0.74 | GPR119 (0.44) | OGADHFRGPR119 | |
| SCHEMBL10085632 | 0.72 | SMN1; SMN2 (0.50) | OGADHFRHDAC6GPR119 | |
| SCHEMBL23559669 | 0.71 | SORD (0.39) | OGA | |
| SCHEMBL26875834 | 0.71 | DHFR (0.40) | OGADHFRTIPARPGPR119 | |
| SCHEMBL24126289 | 0.71 | GPR119 (0.47) | OGADHFRTIPARPACACBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |