Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 11/20 | 0.64 |
| ▸ | PARP1 | P09874 | 7/20 | 0.64 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | PARP11 | Q9NR21 | 7/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | PRF1 | P14222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19252597 | 0.85 | MAPK1 (0.50) | PARP10PARP1F7F3MAPK1 | |
| SCHEMBL12459041 | 0.84 | PARP10 (0.71) | PARP10PARP1F7F3NPC1 | |
| SCHEMBL19175829 | 0.80 | MAPK1 (0.54) | PARP10PARP1MAPK1NPC1LMNA | |
| SCHEMBL12673265 | 0.79 | SMN1; SMN2 (0.41) | PARP10PARP1F7F3MAPK1 | |
| SCHEMBL792895 | 0.78 | PARP10 (1.00) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL10272904 | 0.78 | SMN1; SMN2 (0.46) | PARP10PARP1MAPK1NPC1LMNA | |
| SCHEMBL10061001 | 0.77 | TDP2 (0.56) | MAPK1NPC1LMNACASP3RAB9A | |
| SCHEMBL12727793 | 0.76 | NPC1 (0.50) | PARP10MAPK1NPC1LMNACASP3 | |
| SCHEMBL8162850 | 0.75 | PARP10 (0.63) | PARP10PARP1F7F3MAPK1 | |
| SCHEMBL20747804 | 0.75 | DRD2 (0.47) | PARP10PARP1MAPK1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |