Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23568275 | 0.88 | MAOA (0.43) | HRH3LSSL3MBTL1L3MBTL3HTR2A | |
| SCHEMBL12073562 | 0.83 | ADRB1 (0.46) | NPC1RAB9AMAPTHRH3ALDH1A1 | |
| SCHEMBL13169263 | 0.83 | KDM4E (0.49) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL28307860 | 0.82 | LSS (0.48) | KDM4ELSSMEN1GAAKMT2A | |
| SCHEMBL22837879 | 0.82 | HRH3 (0.40) | HRH3LSSL3MBTL1L3MBTL3HTR2A | |
| SCHEMBL3567979 | 0.82 | MAPT (0.49) | KDM4ENPC1RAB9AMAPTHRH3 | |
| SCHEMBL14048133 | 0.82 | MAPT (0.45) | KDM4EMAPTHRH3ALDH1A1MEN1 | |
| SCHEMBL21541880 | 0.82 | SLC6A2 (0.46) | MAPTHRH3MEN1KMT2AL3MBTL1 | |
| SCHEMBL4938224 | 0.82 | L3MBTL3 (0.61) | HRH3ALDH1A1L3MBTL1L3MBTL3CHKA | |
| SCHEMBL22837878 | 0.81 | MBTD1 (0.47) | HRH3MEN1ALOX15MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46511-E1 | Fused pyrimidine derivatives for inhibition of tyrosine kinase activity | HANMI SCIENCE CO., LTD. (KR) | 2017-08-15 | — | — | US | disclosed |