Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918585 | 0.80 | NOS3 (0.46) | KDM4EPIK3CDALDH1A1POLBJAK2 | |
| SCHEMBL12941448 | 0.78 | HTT (0.42) | KDM4EPIK3CDALDH1A1 | |
| SCHEMBL22239413 | 0.77 | ALDH1A1 (0.35) | KDM4EPIK3CDALDH1A1POLBTRPV4 | |
| SCHEMBL10325957 | 0.77 | AGBL2 (0.41) | KDM4EPIK3CDALDH1A1POLBJAK2 | |
| SCHEMBL480098 | 0.77 | PIK3CD (0.40) | KDM4EPIK3CDALDH1A1POLBJAK2 | |
| SCHEMBL480214 | 0.77 | PIK3CD (0.33) | KDM4EPIK3CDALDH1A1POLBJAK2 | |
| SCHEMBL4586295 | 0.77 | KDM4E (0.40) | KDM4EPIK3CDALDH1A1POLB | |
| SCHEMBL362107 | 0.77 | CHEK1 (0.37) | KDM4EPIK3CDALDH1A1POLBJAK2 | |
| SCHEMBL2076123 | 0.77 | CHEK1 (0.37) | KDM4EPIK3CDALDH1A1POLBJAK2 | |
| SCHEMBL12459073 | 0.75 | ALDH1A1 (0.35) | KDM4EPIK3CDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |