Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Triethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 5/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triethylene Glycol SCHEMBL15525927 | 0.97 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Tetraethylene Glycol SCHEMBL216925 | 0.97 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Triethylene Glycol SCHEMBL18546565 | 0.97 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Di(Hydroxyethyl)Ether SCHEMBL1924542 | 0.97 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Triethylene Glycol SCHEMBL55649 | 0.97 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Tetraethylene Glycol SCHEMBL23931240 | 0.94 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Triethylene Glycol SCHEMBL1204191 | 0.94 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Di(Hydroxyethyl)Ether SCHEMBL3719081 | 0.94 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Diethylene Glycol Monoethyl Ether SCHEMBL1044116 | 0.94 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2ATSHRMAPK1 | |
| Diethylene Glycol Monoethyl Ether SCHEMBL3341006 | 0.94 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2ATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8025704-B2 | Matting additive for blond hair dyeing | HENKEL AG & CO. KGAA (DE) | 2011-09-27 | — | — | US | claimed |
| US-20110126361-A1 | Matting Additive for Blond Hair Dyeing | MANNECK HARTMUT | 2011-06-02 | — | — | US | claimed |
| US-10987289-B2 | Agent for bleaching hair with an initially red or red-blonde hair color | HENKEL AG & CO. KGAA (DE) | 2021-04-27 | — | — | US | disclosed |
| US-20180133127-A1 | AGENT FOR BLEACHING HAIR WITH AN INITIALLY RED OR RED-BLONDE HAIR COLOR | HENKEL AG & CO. KGAA (DE) | 2018-05-17 | — | — | US | disclosed |
| US-8025704-B2 | Matting additive for blond hair dyeing | HENKEL AG & CO. KGAA (DE) | 2011-09-27 | — | — | US | disclosed |
| US-20110126361-A1 | Matting Additive for Blond Hair Dyeing | MANNECK HARTMUT | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110126361-A1 | Matting Additive for Blond Hair Dyeing | LDHB, HMBS, HBB | ALDH1A1 2121/4885MEN1 1844/4885KMT2A 920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.