Sugi Predict

Sugi Predict / Compounds / SCHEMBL19253457

SCHEMBL19253457

SCHEMBL19253457

Brc1cc(Br)n(C2CCCCO2)n1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.38
▸ POLB P06746 2/20 0.38
▸ LMNA P02545 2/20 0.38
▸ CYP4F2 P78329 3/20 0.38
▸ CYP4A11 Q02928 3/20 0.38
▸ KMT2A Q03164 2/20 0.37
▸ GAA P10253 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ RET P07949 7/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ RXRA P19793 1/20 0.35
▸ RXRB P28702 1/20 0.35
▸ RXRG P48443 1/20 0.35
▸ ATR Q13535 3/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ ESR1 P03372 1/20 0.31
▸ MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29078420 0.84 CYP4F2 (0.36) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL22449667 0.84 CYP4F2 (0.44) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL19641656 0.84 GAA (0.44) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL19300191 0.84 CYP4F2 (0.36) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL25586334 0.83 RET (0.41) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL25196116 0.81 ALDH1A1 (0.38) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL29238553 0.81 RET (0.37) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL23533607 0.81 ALDH1A1 (0.38) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL25437502 0.80 CYP4F2 (0.39) ALDH1A1POLBLMNACYP4F2CYP4A11
SCHEMBL18758369 0.80 CYP4F2 (0.37) ALDH1A1POLBLMNACYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122010905-A Pyrazolyl derivatives as anticancer agents 诺华股份有限公司 2026-05-12 — — CN disclosed
EP-4344702-B1 PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS NOVARTIS AG (CH) 2026-01-28 — — EP disclosed
EP-4602041-A1 HPK1 INHIBITORS AND METHODS OF USE THEREOF Arcus Biosciences, Inc. (US) 2025-08-20 — — EP disclosed
EP-4539840-A1 KINASE MODULATORS AND METHODS OF USE THEREOF Neuron23, Inc. (US) 2025-04-23 — — EP disclosed
US-20250122171-A1 Substituted Amine Compounds, Compositions and Methods of Use DEEP APPLE THERAPEUTICS, INC. 2025-04-17 — — US disclosed
WO-2025076285-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME DELPHIA THERAPEUTICS, INC. (US) 2025-04-10 — — WO disclosed
CN-119730846-A Kinase modulators and methods of use thereof 神经元23公司 2025-03-28 — — CN disclosed
WO-2025064534-A1 SUBSTITUTED AMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE DEEP APPLE THERAPEUTICS, INC. (US) 2025-03-27 — — WO disclosed
CN-119431394-A Pyridazinone derivatives and medical application thereof 杭州百新生物医药科技有限公司 2025-02-14 — — CN disclosed
US-20250018068-A1 4H-IMIDAZO[1,5-B]PYRAZOLE DERIVATIVES FOR DIAGNOSIS AC IMMUNE SA (CH) 2025-01-16 — — US disclosed
EP-3419978-B1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS PFIZER (US) 2020-04-15 — — EP disclosed
EP-3419978-B1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS PFIZER (US) 2020-04-15 — — EP disclosed
US-20190071448-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES PFIZER INC. (US) 2019-03-07 — — US disclosed
US-20190071448-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES PFIZER INC. (US) 2019-03-07 — — US disclosed
EP-3419978-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS Pfizer Inc (US) 2019-01-02 — — EP disclosed
US-10144738-B2 Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives PFIZER INC. (US) 2018-12-04 — — US disclosed
WO-2017144995-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS PFIZER INC. (US) 2017-08-31 — — WO disclosed
US-20170240552-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES PFIZER INC. (US) 2017-08-24 — — US disclosed
US-20170240552-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES PFIZER INC. (US) 2017-08-24 — — US disclosed
US-20170240552-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES PFIZER INC. (US) 2017-08-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250018068-A1 4H-IMIDAZO[1,5-B]PYRAZOLE DERIVATIVES FOR DIAGNOSIS SNCA, PARK7, SYNJ1 ALDH1A1 810/4885POLB 2906/4885LMNA 2305/4885
US-20250122171-A1 Substituted Amine Compounds, Compositions and Methods of Use MRGPRX2, MRGPRX1, MRGPRX4 ALDH1A1 2569/4885POLB 2793/4885LMNA 1645/4885
US-10144738-B2 Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives JAK1, JAK2, JAK3 ALDH1A1 1666/4885POLB 3881/4885LMNA 3403/4885
US-20170240552-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES CBR3, CNR1, CCR6 ALDH1A1 3564/4885POLB 3581/4885LMNA 3565/4885
US-20190071448-A1 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES CBR3, CNR1, CCR6 ALDH1A1 3564/4885POLB 3581/4885LMNA 3565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.