SCHEMBL1925385

SCHEMBL1925385

O=C(CC(=O)C(F)(F)F)c1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLOD2 O00469 5/20 1.00
PLOD3 O60568 3/20 1.00
PLOD1 Q02809 3/20 1.00
ALDH1A1 P00352 4/20 0.50
HDAC1 Q13547 2/20 0.50
APP P05067 1/20 0.50
GAA P10253 1/20 0.50
HCAR3 P49019 1/20 0.50
HCAR2 Q8TDS4 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
THRB P10828 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
F7 P08709 1/20 0.49
F3 P13726 1/20 0.49
SARM1 Q6SZW1 1/20 0.49
SIRT2 Q8IXJ6 1/20 0.49
SIRT6 Q8N6T7 1/20 0.49
SIRT1 Q96EB6 1/20 0.49
SIRT3 Q9NTG7 1/20 0.49
SIRT5 Q9NXA8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10320930 0.84 PLOD2 (0.89) PLOD2PLOD3PLOD1ALDH1A1HDAC1
SCHEMBL29554726 0.84 PLOD2 (0.89) PLOD2PLOD3PLOD1ALDH1A1HDAC1
SCHEMBL15395343 0.80 PLOD2 (0.69) PLOD2PLOD3PLOD1ALDH1A1L3MBTL1
SCHEMBL8521979 0.79 PLOD2 (0.66) PLOD2PLOD3PLOD1ALDH1A1HDAC1
SCHEMBL4625207 0.79 PLOD2 (1.00) PLOD2PLOD3PLOD1ALDH1A1HDAC1
SCHEMBL2694778 0.79 PLOD2 (0.79) PLOD2PLOD3PLOD1ALDH1A1HDAC1
SCHEMBL30440488 0.79 PLOD2 (1.00) PLOD2PLOD3PLOD1ALDH1A1HDAC1
SCHEMBL1924749 0.79 PLOD2 (1.00) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL523476 0.78 PLOD2 (0.69) PLOD2PLOD3PLOD1ALDH1A1HDAC1
SCHEMBL21408730 0.78 PLOD2 (0.67) PLOD2PLOD3PLOD1ALDH1A1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3883577-B1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY UNIV CASE WESTERN RESERVE (US) 2026-04-08 EP disclosed
US-20250304537-A1 HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME REPARE THERAPEUTICS INC. (CA) 2025-10-02 US disclosed
US-12336982-B2 Compositions and methods of modulating short-chain dehydrogenase activity RODEO THERAPEUTICS CORPORATION (US) 2025-06-24 US disclosed
US-20250161277-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2025-05-22 US disclosed
EP-4526293-A1 HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME Repare Therapeutics Inc. (CA) 2025-03-26 EP disclosed
WO-2024215863-A2 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2024-10-17 WO disclosed
WO-2023220831-A1 HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME REPARE THERAPEUTICS INC. (CA) 2023-11-23 WO disclosed
EP-3722379-B1 INK COMPOSITION AND PRINTED MATTER DAINIPPON PRINTING CO LTD (JP) 2023-10-11 EP disclosed
EP-3783072-B1 INK COMPOSITION, PRINTED PRODUCT, AND AUTHENTICITY DETERMINATION METHOD DAINIPPON PRINTING CO LTD (JP) 2023-04-12 EP disclosed
US-20230039604-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY RODEO THERAPEUTICS CORPORATION 2023-02-09 US disclosed
EP-1960367-A2 SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS Boehringer Ingelheim International GmbH (DE) 2008-08-27 EP disclosed
US-20080051421-A1 Pyrazolo-pyridine WICHMANN JUERGEN 2008-02-28 US disclosed
US-7329662-B2 Pyrazolo-pyridine HOFFMANN-LA ROCHE INC. (US) 2008-02-12 US disclosed
WO-2007067836-A2 SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-06-14 WO disclosed
WO-2007067836-A2 SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-06-14 WO disclosed
EP-1670801-A1 PYRAZOLO AND IMIDAZO-PYRIMIDINE DERIVATIVES F. Hoffmann-Roche AG (CH) 2006-06-21 EP disclosed
US-20050130992-A1 Pyrazolo-pyridine F. HOFFMANN-LA ROCHE AG (CH) 2005-06-16 US disclosed
WO-2005040171-A1 PYRAZOLO AND IMIDAZO-PYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2005-05-06 WO disclosed
US-4708494-A Methods and devices for the optical measurement of temperature with luminescent materials KLEINERMAN MARCOS (US) 1987-11-24 US disclosed
US-4444774-A TRANQUILIZERS AMERICAN CYANAMID COMPANY (US) 1984-04-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250161277-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY HPGD, GCDH, HPGDS PLOD2 380/4885PLOD3 613/4885PLOD1 428/4885
US-20250304537-A1 HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME CSNK1A1, CSNK1G1, CSNK2A1 PLOD2 4720/4885PLOD3 3997/4885PLOD1 4412/4885
US-12336982-B2 Compositions and methods of modulating short-chain dehydrogenase activity HPGD, GCDH, HPGDS PLOD2 380/4885PLOD3 613/4885PLOD1 428/4885
US-20050130992-A1 Pyrazolo-pyridine CHRM2, CHRM1, QDPR PLOD2 3738/4885PLOD3 3474/4885PLOD1 3848/4885
US-20230039604-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY HPGD, GCDH, HPGDS PLOD2 380/4885PLOD3 613/4885PLOD1 428/4885
US-20080051421-A1 Pyrazolo-pyridine CHRM2, CHRM1, QDPR PLOD2 3738/4885PLOD3 3474/4885PLOD1 3848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.