Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.47 |
| ▸ | PRKCH | P24723 | 3/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.35 |
| ▸ | PRKCB | P05771 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | LATS1 | O95835 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19256234 | 0.84 | IMPDH2 (0.36) | IMPDH2PRKCHPRKCEPRKCQPRKCD | |
| SCHEMBL9880929 | 0.81 | IMPDH2 (0.56) | IMPDH2PRKCHPRKCEPRKCQPRKCD | |
| SCHEMBL25541010 | 0.80 | SSTR4 (0.46) | PRKCHPRKCEPRKCQPRKCDPRKCB | |
| SCHEMBL22792452 | 0.79 | CLK1 (0.34) | HTR2AHTR2CHTR2B | |
| SCHEMBL22140358 | 0.74 | GAA (0.34) | PRKCHPRKCEPRKCQPRKCDLATS1 | |
| SCHEMBL22794684 | 0.72 | LMNA (0.46) | PRKCHPRKCEPRKCQPRKCDPRKCB | |
| SCHEMBL9883128 | 0.71 | IMPDH2 (0.56) | IMPDH2PRKCHPRKCEPRKCQPRKCD | |
| SCHEMBL22043055 | 0.69 | CYP2E1 (0.36) | CYP3A4CYP2D6LMNACYP1A2CYP2C9 | |
| SCHEMBL22043381 | 0.69 | PRKCH (0.33) | PRKCHPRKCEPRKCQPRKCDCYP3A4 | |
| SCHEMBL19185523 | 0.69 | TDP1 (0.34) | PRKCHPRKCEPRKCQPRKCDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951059-B2 | Dual mechanism inhibitors for the treatment of disease | AERIE PHARMACEUTICALS, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170233381-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | ALCON INC. (CH) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233381-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | RHOA, SLC6A2, ROCK2 | IMPDH2 236/4885PRKCH 129/4885PRKCE 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.