Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1541692 | 0.84 | TAAR1 (0.57) | SLC6A3ALDH1A1TAAR1SLC18A2SIGMAR1 | |
| SCHEMBL13621464 | 0.84 | TAAR1 (0.57) | SLC6A3ALDH1A1TAAR1SLC18A2SIGMAR1 | |
| SCHEMBL13621571 | 0.84 | TAAR1 (0.57) | SLC6A3ALDH1A1TAAR1SLC18A2SIGMAR1 | |
| SCHEMBL18917320 | 0.83 | MAPT (0.48) | SLC6A3CNR2ALDH1A1KMT2ASIGMAR1 | |
| SCHEMBL5981801 | 0.77 | RAB9A (0.54) | CNR2ALDH1A1KMT2AMAPK1POLB | |
| SCHEMBL19257742 | 0.76 | CNR2 (0.48) | SLC6A3CNR2ALDH1A1KMT2ATAAR1 | |
| SCHEMBL9321453 | 0.76 | SLC6A2 (0.59) | SLC6A3ALDH1A1TAAR1SLC18A2SIGMAR1 | |
| SCHEMBL13971483 | 0.75 | ADRB3 (0.49) | ALDH1A1TAAR1SLC18A2SIGMAR1CYP2D6 | |
| Methamphetamine SCHEMBL11146875 | 0.75 | SIGMAR1 (0.72) | ALDH1A1KMT2ATAAR1SLC18A2SIGMAR1 | |
| SCHEMBL11099393 | 0.74 | SMN1; SMN2 (0.49) | ALDH1A1KMT2ATAAR1SLC18A2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | PFIZER INC. (US) | 2020-07-28 | — | — | US | disclosed |
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | NGLY1, TEK, TEKT1 | SLC6A3 1024/4885CNR2 4694/4885ALDH1A1 4715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.