Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CHKA | P35790 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451169 | 0.80 | EPHX1 (0.61) | CYP2D6CYP1A2CYP2C19SLC6A2TAAR1 | |
| SCHEMBL272604 | 0.80 | EPHX1 (0.61) | CYP2D6CYP1A2CYP2C19SLC6A2TAAR1 | |
| SCHEMBL468022 | 0.80 | EPHX1 (0.61) | CYP2D6CYP1A2CYP2C19SLC6A2TAAR1 | |
| SCHEMBL5981801 | 0.80 | RAB9A (0.54) | CNR2ALDH1A1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3282010 | 0.79 | SLC6A2 (0.52) | CNR2CYP2D6CYP1A2CYP2C19SLC6A2 | |
| Hydrochloric Acid SCHEMBL28839661 | 0.78 | EPHX1 (0.58) | CYP2D6CYP1A2CYP2C19SLC6A2TAAR1 | |
| Hydrochloric Acid SCHEMBL27276749 | 0.78 | EPHX1 (0.58) | CYP2D6CYP1A2CYP2C19SLC6A2TAAR1 | |
| SCHEMBL9323047 | 0.77 | EPHX1 (0.52) | CNR2CYP2D6CYP1A2CYP2C19SLC6A2 | |
| SCHEMBL17463566 | 0.77 | EPHX1 (0.52) | CNR2CYP2D6CYP1A2CYP2C19SLC6A2 | |
| SCHEMBL19257741 | 0.76 | SLC6A3 (0.50) | CNR2CYP2D6CYP2C19TAAR1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | PFIZER INC. (US) | 2020-07-28 | — | — | US | disclosed |
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | NGLY1, TEK, TEKT1 | CNR2 4694/4885CYP2D6 4517/4885CYP1A2 4875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.