SCHEMBL19258220

SCHEMBL19258220

Cc1cc(-c2ncnc3cc(CCC(F)(F)F)ccc23)c(C)c(C)c1F

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 2/20 0.33
SCN9A Q15858 3/20 0.33
EGFR P00533 1/20 0.32
IRAK4 Q9NWZ3 1/20 0.31
KIT P10721 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17666808 0.86 SIK2 (0.37) PRKDCSCN9AEGFRIRAK4KIT
SCHEMBL19258029 0.85 IRAK4 (0.33) PRKDCEGFRIRAK4
SCHEMBL19258223 0.83 PRKDC (0.33) PRKDCSCN9AEGFRKIT
SCHEMBL19258222 0.83 SIGMAR1 (0.42) PRKDCSCN9AKIT
SCHEMBL19258028 0.82 SIGMAR1 (0.37) PRKDCSCN9AIRAK4
SCHEMBL26060620 0.80
SCHEMBL19143219 0.79 PIM1 (0.38) PRKDCSCN9AEGFRKIT
SCHEMBL19258070 0.78 PRKDC (0.34) PRKDCSCN9AEGFR
SCHEMBL19143202 0.77 GRM2 (0.32) PRKDCSCN9AEGFR
SCHEMBL21204322 0.75 ADORA2A (0.46) EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3205658-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES Universal Display Corporation (US) 2017-08-16 EP disclosed