Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | UBE2N | P61088 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131072 | 0.77 | ITGB2 (0.52) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL118249 | 0.77 | ABCG2 (0.35) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL395819 | 0.65 | KDM4E (0.33) | ITGB2ICAM1ITGALABCG2MEN1 | |
| SCHEMBL29788643 | 0.64 | MAOA (0.41) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL29788642 | 0.64 | MAOA (0.41) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL895328 | 0.64 | MAOA (0.41) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL8517 | 0.64 | MAOA (0.41) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL107468 | 0.64 | MAOA (0.41) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL1162919 | 0.64 | ALOX12 (0.33) | LMNAMAPTTSHR | |
| SCHEMBL11557711 | 0.62 | MAOA (0.39) | ITGB2ICAM1ITGALLMNACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416947-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | CeMM - Forschungszentrum für Molekulare Medizin GmbH (AT) | 2018-12-26 | — | — | EP | claimed |
| WO-2017140728-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2017-08-24 | — | — | WO | claimed |
| EP-3416947-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | CeMM - Forschungszentrum für Molekulare Medizin GmbH (AT) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017140728-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2017-08-24 | — | — | WO | disclosed |