Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2289477 | 0.81 | KDM4E (0.50) | KDM4EALPLGAAMCL1GSK3B | |
| SCHEMBL5133946 | 0.75 | KDM4E (0.45) | KDM4EALPLGAAMCL1GSK3B | |
| SCHEMBL2046783 | 0.74 | MAPK1 (0.32) | KDM4EALDH1A1HSD17B10TSHRMAPK1 | |
| SCHEMBL5576841 | 0.74 | PRKCZ (0.43) | IKBKETBK1CYP1A2 | |
| SCHEMBL28065244 | 0.72 | HPRT1 (0.52) | KDM4EALPLGAAGSK3BCDK5 | |
| SCHEMBL378547 | 0.72 | DNMT1 (0.38) | KDM4EALPLGAAMCL1ALDH1A1 | |
| SCHEMBL26259996 | 0.72 | AURKA (0.48) | KDM4EALPLGAAGSK3BCDK5 | |
| Hydrochloric Acid SCHEMBL6554454 | 0.71 | DNMT1 (0.37) | KDM4EALPLGAAMCL1ALDH1A1 | |
| SCHEMBL27263879 | 0.71 | ALDH1A1 (0.53) | KDM4EALPLGAAGSK3BNISCH | |
| SCHEMBL25302086 | 0.70 | ALDH1A1 (0.59) | KDM4EALPLGAANISCHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3416946-A1 | TETRACYCLIC PYRIDONE COMPOUNDS AS ANTIVIRALS | Novartis AG (CH) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017140821-A1 | TETRACYCLIC PYRIDONE COMPOUNDS AS ANTIVIRALS | NOVARTIS AG (CH) | 2017-08-24 | — | — | WO | disclosed |